Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-127-6 | CAS number: 40880-51-1
VIABILITY / MORTALITY / MACROSCOPIC FINDINGS
There were no deaths during the course of the study, hence no necropsies were performed.
CLINICAL SIGNS, SYSTEMIC
No symptoms of systemic toxicity were observed in the animals.
SKIN EFFECT IN THE INDUCTION
As test article at 50 % in bi-distilled water stained the skin violet, it was not possible to determine whether erythema was present or not. However, no oedema was observed.
SKIN EFFECT IN THE CHALLENGE
Discrete/patchy erythema was observed in 8 (at the 24 -hour reading) and 4 (at the 48 - hour reading) out of 20 test animals after treatment with test article at 50 % in bi-distilled water. No skin reactions were observed in animals of the control group treated with same test article, vehicle and concentration.
The body weight of animals was within the range commonly recorded for animals of this strain and age.
The skin sensitising potential of test substance was evaluated using a Buheler test, according to the OECD guideline 406.
20 female animals of test group were treated topically with test substance at 50 % in bi-distilled water once a week for a 3 week induction phase. 2 weeks after the final induction application, animals were challenged with the same test article concentration of 50 % in bi-distilled water as used for induction. The 10 animals of the control group were not treated during the induction but were treated once at challenge with test substance at 50 % in bi-distilled water.
In this study, 40 % of animals in test group showed skin reactions after challenge treatment performed with the highest non-irritant concentration of test substance at 50 % in bi-distilled water. No skin reactions were observed in the control group treated in the same conditions during the challenge phase.
Under experimental conditions, the substance is considered as a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again