Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-127-6 | CAS number: 40880-51-1
Endpoint summary
Administrative data
Description of key information
The substance is non irritatant to the skin and eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Local changes induced by the substance at the site of contact, namely skin and eye, were evaluated irrespective of whether the substance may become systemically available or not. Skin and eye irritation potentials were tested on rabbits by topical application and instillation, respectively.
As for dermal application, very slight erythema was noted after 24 h on both intact and abraded skin in 2/6 and 3/6 rabbits, respectively. Such signs were no more evident at the 72 h observation time point. No signs of oedema were noted over the whole observation period.
As for eye instillation, no effects on cornea and iris were seen. Slight effects on conjuctivae were seen in both rinsed and unrinsed eye, with lower frequency in rabbits with rinsed eye. Such effects were reversible within 6 days.
Under test conditions, during the observation period, the substance did not induce systemic toxicity nor mortality.
Justification for classification or non-classification
The substance is not classified according to the CLP Regulation (EC 1272/2008).
As for skin irritation, mean scores for erythema and oedema over 24 h, 48 h (not measured, assumed to be equal to the highest value between 24 and 72 h) and 72 h were below the threshold for classification, i.e. 2.3, in all animals tested.
As for eye irritation, average scores over 24, 48 and 72 hours for all animals were below the thresholds for classification, i.e. 1 for cornea and iris, and 2 for conjuctivae redness and chemosis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
