Registration Dossier

Administrative data

Description of key information

Acute toxicity in rats

LD50 = 3980 mg/kg, corresponding to 1592 mg/kg a.i..

LD50 = 4970 mg/kg, corresponding to 1759 mg/kg a.i..

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
1 592 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

According to the CLP Regulation (EC 1272/2008), substances can be allocated to one of four toxicity categories based on acute toxicity by oral, dermal or inhalation route according to numeric criteria. Acute toxicity values are expressed as LD50 (oral, dermal) or LC50 (inhalation) values as well as acute toxicity estimates (ATE).

 

In available studies in rats, oral LD50 values of 1592 and 1759 mg a.i./kg bw was found.

Accordingly, the test substance was classified for acute oral toxicity in category 4 (LD50 between 300 and 2000 mg/kg bw) in the CLP Regulation (EC 1272/2008).