Registration Dossier

Administrative data

Description of key information

Two acute oral toxicity data are available, as secondary source, for desipramine hydrochloride:

mouse, LD50, oral = 315 mg/kg

rat, LD50, oral = 871 mg/kg.

The substance is classified as Acute Tox. 4 H302.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Reference:
Composition 0
Test material information:
Composition 1
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
315 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Mouse oral LD50 for desipramine hydrochloride is 315 mg/kg.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Reference:
Composition 0
Test material information:
Composition 1
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Dose descriptor:
LD50
Effect level:
871 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Rat oral LD50 for desipramine hydrochloride is 871 mg/kg.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
315 mg/kg bw

Additional information

Justification for classification or non-classification