2-methyl-1-phenylpropan-2-ol

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VIII

Author:

Carpenter, Weil and Smyth.

Year:

1974

Bibliographic source:

Toxicol Appl Pharmacol 28, 313-319.

Reference 2

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth Jr., Carpenter, Well, Pozzani and Striegel.

Year:

1962

Bibliographic source:

American Industrial Hygiene Association Journal, 23:2, 95-107

Reference 3

Reference Type:

publication

Title:

Chemical Burns of the Rabbit Cornea

Author:

Carpenter and Smyth

Year:

1946

Bibliographic source:

American Journal of Ophthalmology Vol. 29 (11), Pages 1363-1372

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The method is described in Smyth et al., 1962 and Carpenter and Smyth 1946. Eye irritation was evaluated using 5 albino rabbits per dose. The test material was applied to the centre of the cornea while the lids are retracted, and approximately 1 minute later, the lids are released. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methyl-4-phenylbutan-2-ol

EC Number:

203-074-4

EC Name:

2-methyl-4-phenylbutan-2-ol

Cas Number:

103-05-9

Molecular formula:

C11H16O

IUPAC Name:

2-Methyl-4-phenyl-2-butanol

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

Undiluted

Duration of treatment / exposure:

18 - 24 hours

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: corneal necrosis

Basis:

mean

Time point:

other: Only 24hr timepoint

Score:

8

Max. score:

10

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Results 2

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

24/48/72 h

Reversibility:

not specified

Remarks on result:

not measured/tested

Results 3

Irritation parameter:

iris score

Basis:

mean

Time point:

24/48/72 h

Reversibility:

not specified

Remarks on result:

not measured/tested

Results 4

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

24/48/72 h

Reversibility:

not specified

Remarks on result:

not measured/tested

Results 5

Irritation parameter:

chemosis score

Basis:

mean

Time point:

24/48/72 h

Reversibility:

not specified

Remarks on result:

not measured/tested

Applicant's summary and conclusion

Interpretation of results:

other: irritating

Conclusions:

Phenylethyl Alcohol is an irritant to rabbit eyes.

Executive summary:

In an eye irritation study (Carpenter et al., 1974) Phenylethyl Alcohol (undiluted) was applied to the centre of the cornea of 5 albino rabbits. The eye was examined in strong diffuse daylight 18 - 24 hours later, stained with fluorescein, and the injury scored. No vehicle was used.

Eye injury was graded according to the following 10-point scale based upon the degree of corneal necrosis that resulted. The corneal injury in rabbits was indicated as 8 out of 10. Based on the results of this study, Phenylethyl Alcohol was considered to be an eye irritant.