Registration Dossier

Physical & Chemical properties

Vapour pressure

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 01 December 2016 to 09 December 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Conclusions:
The vapour pressure at 25°C was determined to be < 2.1E-08 Pa.
The vapour pressure at 20°C was determined to be < 1.3E-08 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950. The vapour pressure at 25°C was determined to be <2.1E-08 Pa. The vapour pressure at 20°C was determined to be <1.3E-08 Pa.

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2015-07-24 to 2016-06-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
a pan was used instead of a plate
GLP compliance:
not specified
Other quality assurance:
other: ISO 14001
Type of method:
effusion method: isothermal thermogravimetry
Test no.:
#1
Temp.:
50 °C
Vapour pressure:
0.163 Pa
Test no.:
#2
Temp.:
60 °C
Vapour pressure:
0.186 Pa
Test no.:
#3
Temp.:
70 °C
Vapour pressure:
0.21 Pa
Test no.:
#4
Temp.:
80 °C
Vapour pressure:
0.21 Pa

The evaporation rate of the test substance was determined at 5 temperatures between 60 and 175°C. The equation in the plot above was used to calculate the vapor pressure. See results in Table 8.2. The calculated vapor pressure based on evaporation rates was plotted against temperature in order to derive the vapor pressure equation. The calculated vapor pressures were done in mm Hg because all calibration tables were done in this unit. After, the calculated vapor pressures for the test substance were converted to Pascal as per OECD Guideline.

Table 8.2. Experimental evaporation rates of test substance with calculated vapor pressure.

Temp. (°C)

Evaporation Rate (µg/min)

log Evaporation Rate (µg/min)

Temp. (1/K)

Log Vapor Pressure (mmHg)

Calculated Vapor Pressure (mm Hg)

Calculated Vapor Pressure (Pascal)

60

0.0684

-1.164943898

0.003002

-2.855596556

0.001394

0.1859

80

0.0875

-1.057991947

0.002832

-2.745346474

0.001797

0.2396

50

0.0601

-1.221125528

0.003095

-2.913510686

0.001220

0.1627

70

0.0770

-1.113509275

0.002914

-2.802575817

0.001576

0.2101

 

Conclusions:
The vapour pressure of Cyastat SN was determined to be equal to 0.16 Pa at 50°C.
Executive summary:

Density of Cyastat SN has been determined according to OECD test guideline 104. Using TGA method, the vapour pressure of the test substance was determined to be 0.16 Pa at 50 °C.

Description of key information

The vapour pressure at 20°C was determined to be < 1.3E-08 Pa.

The vapour pressure at 25°C was determined to be < 2.1E-08 Pa.

The vapour pressure at 50°C was determinated to be equal to 0.16 Pa.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

Two experimental studies were selected as key study with different temperature.

It was performed according to OECD 104 guideline.

The key value is proposed as < 2.1E-08 Pa at 25°C.