Registration Dossier
Registration Dossier
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EC number: 200-023-8 | CAS number: 50-28-2
Flammability
Administrative data
Link to relevant study record(s)
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: UN test procedure "Recommendations on the Transport of Dangerous Goods-Manual of Tests and Criteria" (UN-MTC), Part III, sub-section 33.2.1.4.1, Test N.1 `Test method for readily combustible solids'.
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Key result
- Test procedure:
- burning rate test with wetted zone
- Remarks on result:
- other: The test substance melted when approached by the ignition flame. The substance did not burn up.
- Remarks:
- No further testing is required.
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- The substance is classified as a not readily combustible solid. As a conclusion the substance is a non flammable solid.
- Executive summary:
The test was performed as stipulated in UN test procedure "Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria" (UN-MTC), Part III, sub-section 33.2.1.4.1, Test N.1 `Test method for readily combustible solids". Estradiol in its delivery state melted when approached by the ignition flame. The substance did not burn up. Therefore Estradiol is classified as a not readily combustible solid when tested according to UN-MTC Procedure N.1. As a conclusion the substance is a non flammable solid.
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: VDI 2263, Part 1 ‘Test Methods for the Determination of the Safety Characteristic of Dusts’
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Key result
- Test procedure:
- other: The sample in its delivery state and an inert reference substance are heated up to 380 °C at a rate of 0.5 K/min in an air flow of about 20 L/h.
- Max. temp. reached:
- 380
- Result:
- negative outcome (no effect observed)
- Remarks:
- The wire mesh basket was empty after the measurement.
- Remarks on result:
- other: No exothermic effects were determined up to the point at which the test substance melted.
- Interpretation of results:
- not classified based on GHS criteria
- Conclusions:
- The substance is classified as a not self-heating substance in the sense of CLP Annex I, 2.11.
- Executive summary:
According to the German standard "VDI 2263", Part 1 ‘Test Methods for the Determination of the Safety Characteristic of Dusts’ Estradiol is not a self-heating substance in the sense of CLP Annex I, 2.11. The determination according to UN-MTC Procedure N.4 (Bowes-Cameron-Cage-Test) is not necessary.
Referenceopen allclose all
The substance in its delivery state was measured. The test substance melted when approached by the ignition flame. The substance did not burn up. No further testing was required.
Description of key information
a.) Flammability: Estradiol is a no flammable solid according to UN-MTC Procedure N.1.
b.) Pyrophoric properties: Estradiol did not deliver indications of pyrophoric properties during the realization of other tests. The determination according to UN-MTC Procedure N.2 is not necessary.
c.) Contact with water: A review of the structure suggests that there are no chemical groups present that would imply pyrophoric properties or flammability on contact with water. A review of handling and use implies no pyrophoric properties or flammability on contact with water. Testing according to UN Procedure N.5 is not necessary.
d.) Self-heating substances: Estradiol is not a self-heating substance in the sense of CLP Annex I, 2.11.
Key value for chemical safety assessment
- Flammability:
- not classified
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
