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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: p-methylacetophenone
Author:
D. L. J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 933

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute Dermal Toxicity Study of 4'-methylacetophenone in Rabbits
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4'-methylacetophenone
EC Number:
204-514-8
EC Name:
4'-methylacetophenone
Cas Number:
122-00-9
Molecular formula:
C9H10O
IUPAC Name:
1-(4-methylphenyl)ethan-1-one
Details on test material:
Name - 4'-methylacetophenone
InChI - 1S/C9H10O/c1-7-3-5-9(6-4-7)8(2)10/h3-6H,1-2H3
Smiles - c1(C(C)=O)ccc(C)cc1
- Molecular formula (if other than submission substance):C9H10O
- Molecular weight (if other than submission substance):134.177 g/mole
- Substance type:Organic
Specific details on test material used for the study:
Name - 4'-methylacetophenone
InChI - 1S/C9H10O/c1-7-3-5-9(6-4-7)8(2)10/h3-6H,1-2H3
Smiles - c1(C(C)=O)ccc(C)cc1
- Molecular formula (if other than submission substance):C9H10O
- Molecular weight (if other than submission substance):134.177 g/mole
- Substance type:Organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality observed at 2000 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be >2000 mg/kg bw, when rabbits were treated with 4'-Methylacetophenone (122-00-9) by dermal application.
Executive summary:

In an acute dermal toxicity study,rabbits were treated with 4'-Methylacetophenone (122-00-9) at the concentration of 2000mg/kg bw. No mortality was observed at 2000 mg/kg bw. Therefore,LD50 was considered to be >2000 mg/kg bw, whenrabbits were treated with 4'-Methylacetophenone by dermal application.