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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
For this endpoint a one-to-one read across was performed to a chemical similar compound of the same chemical class with a comparable phys. chem. profile and similar response in biological assays. The relevant study was performed according to GLP and the methods applied are fully compliant with OECD Guideline 209. A read across justification is provided in the attached document (Chapter 13).
Reason / purpose:
read-across source
Key result
Duration:
3 h
Dose descriptor:
EC10
Effect conc.:
> 1 080 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration

Description of key information

The toxicity of the source substance on microorganisms was investigated in an activated sludge respiration inhibition test according to OECD Test Guideline 209 under GLP-conditions.

In a limit test with the nominal concentration of 1080 mg/L no (statistically significant) inhibitory effect of the substance was observed as compared to the blank control after 3 hours of incubation.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
1 080 mg/L

Additional information