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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: BCBQ4646V
- Expiration date of the lot/batch: 31.07.2017 (re-test date)
- Purity test date: na

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no
Key result
Water solubility:
ca. 597.7 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 500 g/L
Incubation duration:
>= 3 - <= 5 d
Temp.:
20 °C
pH:
ca. 4.4
Water solubility:
ca. 580.4 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2 200 g/L
Incubation duration:
>= 3 - <= 5 d
Temp.:
10 °C
pH:
ca. 4.1
Details on results:
Water solubility standard deviation at 10°C: 2.35
Water solubility standard deviation at 20°C: 2.10
A preliminary test was conducted, which showed a water solubility of approx.1000 g/L at 20°C.

The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by HPLC.

The mean water solubility (3 replicates on three days) was determined at 20°C as 597.7 g/L.

Water solubility at 20°C:

 Equilibration time  measurement 1  measurement 2  measurement 3  mean
 Day 3 596.8   602.8  600.4  600.0
 Day 4 597.4  600.0  593.8  597.1
 Day 5 591.3  604.5  592.2  596.0
          overall mean  597.7
          overall standard deviation

 2.10

Executive summary:

The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by a validated HPLC.

The mean water solubility (3 replicates over three days) was determined at 20°C as 597.7 g/L and at 10°C as 580.4 g/L. The mean pH of the solutions was 2.4.

Description of key information

The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by HPLC (SIA73).

The mean water solubility (3 replicates on three days) was determined at 20°C as 597.7 g/L.

Key value for chemical safety assessment

Water solubility:
597.7 g/L
at the temperature of:
20 °C

Additional information

water solubility of 580.4 g/L at 10°C