Registration Dossier
Registration Dossier
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EC number: 214-478-5 | CAS number: 1132-61-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2020-03-17 to 2020-03-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 597.7 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 500 g/L
- Incubation duration:
- >= 3 - <= 5 d
- Temp.:
- 20 °C
- pH:
- ca. 4.4
- Water solubility:
- ca. 580.4 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 2 200 g/L
- Incubation duration:
- >= 3 - <= 5 d
- Temp.:
- 10 °C
- pH:
- ca. 4.1
- Details on results:
- Water solubility standard deviation at 10 °C: 2.35
Water solubility standard deviation at 20 °C: 2.10
A preliminary test was conducted, which showed a water solubility of approx.1000 g/L at 20 °C. - Conclusions:
- The water solubility of the substance was determined to be 597.7 g/L at 20 °C.
- Executive summary:
The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 and Regulation (EC) No 440/2008, method A.6 by the flask method. The mean water solubility (3 replicates on three days) was determined at 20 °C as 597.7 g/L.
Reference
The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 by HPLC.
The mean water solubility (3 replicates on three days) was determined at 20 °C as 597.7 g/L.
Water solubility at 20 °C:
Equilibration time | measurement 1 | measurement 2 | measurement 3 | mean |
Day 3 | 596.8 | 602.8 | 600.4 | 600.0 |
Day 4 | 597.4 | 600.0 | 593.8 | 597.1 |
Day 5 | 591.3 | 604.5 | 592.2 | 596.0 |
overall mean | 597.7 | |||
overall standard deviation | 2.10 | |||
Since the measured concentrations of Day 2 and Day 3 did not differ by more than 15 % and showed no tendency of increasing values the test results were satisfactory according to the guideline. The mean value of the measurements was calculated.
Description of key information
The water solubility of the substance was determined to be 597.7 g/L at 20 °C (reference 4.8-1).
Key value for chemical safety assessment
- Water solubility:
- 597.7 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the substance was determined in an experimental study under GLP conditions according to OECD Test Guideline 105 and Regulation (EC) No 440/2008, method A.6 by the flask method. The mean water solubility (3 replicates on three days) was determined at 20 °C as 597.7 g/L.
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