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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

3h EC50 (activated sludge, domestic) = 135 mg/L (respiration inhibition test, similar to OECD 209)

Key value for chemical safety assessment

EC50 for microorganisms:
135 mg/L

Additional information

Two reliable studies investigating toxic effects of Sodium dodecyl sulfate (CAS 151-21-3) to aquatic microorganisms are available. The key study was performed using activated sludge from a municipal sewage treatment plant (Dutka 1983). The non-GLP test was performed according to a guideline similar to OECD 209. EC50 values of 188 and 135 mg/L (nominal concentrations) were obtained for the endpoint respiration inhibition after 30 minutes and 3 hours of exposure, respectively.

In addition, supporting studies are availabe with (i) the substance itself (CAS 151-21-3) and a read across substance (CAS 90583-18-9) containing C14 alkyl sulfate which is considered to be the most toxic chain length based on the data available for memebers of the alkyl sulfate category.

One non-GLP study with sodium dodecyl sulfate (CAS 151-21-3) was performed by Dutka and Kwan (1984) using synthetic activated sludge as inoculum. The respiration rate was measured after a contact time of 3 hours. The 3h-IC50 value was determined to be 480 mg/L based on the nominal concentration.

One study with the read across substance Sulfuric acid, mono C12-14, alkyl ester, compounds with triethanolamine (CAS 90583-18-9) was performed according to GLP and DIN guideline 38412 part 8 using Pseudomonas putida as test organism (Guhl 1992). The growth inhibition was measured after 16 hours of exposure. The 16-h EC10 value was determined to be 1084 mg a.i./L (nominal concentration).

The supporting studies indicate that the EC50 value of 135 mg/L may overestimate the toxicity of sodium dodecyl sulfate. However, in order to be consistently conservative, the 3-hour EC50 value of 135 mg/L obtained by Dutka (1983) was used as key study and for PNEC STP derivation.