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EC number: 601-601-6
CAS number: 119345-04-9
A single application of 2000 mg/kg of neat DOWFAX 2A1 was
applied to the clipped trunks of two male New Zealand White rabbits
under an impervious, occlusive bandage. Erythema, edema and burns were
observed, at the application site, immediately after removing the wrap.
Due to the fact that, in the previous skin irritation test, five
consecutive daily applications of this test material to an intact site,
and three to a slightly abraded site (minor incision through the stratum
corneum of insuffiaent depth to produce bleeding), caused only very
slight irritation to the skin, it is felt that these burns may be a
result of the procedure used in preparing the animals for testing. These
observations were noted through test day four in one animal, and test
day eight in the other. By test day eight, both animals were observed
with scaling which persisted through the end of the study.
Administration of DOWFAX 2A1 at 2000 mg/kg had no apparent effect on
body weight during the two-week observation period. The estimated acute
dermal LD50 for male New Zealand White rabbits was greater than 2000
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