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EC number: 601-601-6 | CAS number: 119345-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guideline/s and GLP, but the report contains sufficient data for interpretation of study results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single application of 2000 mg/kg of neat DOWFAX 2A1 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Following exposure, observations and body weights were recorded over a 2-week period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- EC Number:
- 601-601-6
- Cas Number:
- 119345-04-9
- Molecular formula:
- C24H32O7S2Na2
- IUPAC Name:
- Benzene, 1,1'-oxybis-, tetrapropylene derivs., sulfonated, sodium salts
- Details on test material:
- Test material: Dowfax 2A1
Source: Specialty Chemicals, The Dow Chemical Company
Properties: Amber liquid
pH= 7.0
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No additional data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- In the acute dermal absorption test, animals were prepared 24 hours prior to dosing by clipping the trunk. A single application of 2000 mg/kg of neat DOWFAX 2A1 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Residual test material was washed off when the bandage was removed 24 hours after application, and the animals were collared until dry to prevent grooming of the application site.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 male rabbits/dose
- Control animals:
- no
- Details on study design:
- In the acute dermal absorption test, animals were prepared 24 hours prior to dosing by clipping the trunk. A single application of 2000 mg/kg of neat Dowfax 2A1 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Residual test material was washed off when the bandage was removed 24 hours after application, and the animals were collared until dry to prevent grooming of the application site. Following exposure, observations and body weights were recorded over a 2-week period.
- Statistics:
- None
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: Erythema, edema and burns were observed, at the application site, immediately after removing the wrap. Due to the fact that, in the previous skin irritation test, five consecutive daily applications of this test material to an intact site, and three to a
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- The estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
- Executive summary:
A single application of 2000 mg/kg of neat DOWFAX 2A1 was applied to the clipped trunks of two male New Zealand White rabbits under an impervious, occlusive bandage. Erythema, edema and burns were observed, at the application site, immediately after removing the wrap. Due to the fact that, in the previous skin irritation test, five consecutive daily applications of this test material to an intact site, and three to a slightly abraded site (minor incision through the stratum corneum of insuffiaent depth to produce bleeding), caused only very slight irritation to the skin, it is felt that these burns may be a result of the procedure used in preparing the animals for testing. These observations were noted through test day four in one animal, and test day eight in the other. By test day eight, both animals were observed with scaling which persisted through the end of the study. Administration of DOWFAX 2A1 at 2000 mg/kg had no apparent effect on body weight during the two-week observation period. The estimated acute dermal LD50 for male New Zealand White rabbits was greater than 2000 mg/kg.
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