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EC number: 601-601-6
CAS number: 119345-04-9
Waived: log Pow = -2.68
In accordance with Column 2 of REACh Annex IX, the study need not be
conducted if the substance has a low potential for bioaccumulation (log
Pow < 3) and/or low potential to cross biological membranes. The
estimated log Pow of the substance is -2.68, based on ratio of
solubilities in 1 -octanol and water.
Measured bioconcentration of the structurally-analogous C12 -C14 linear
alkylbenzene sulfonate (LAS) surfactants in fathead minnow and Daphnia
magna ranged from 269 - 1,223 and 500 - 4,000 L/Kg (dry wt.),
respectively. The bioconcentration factors reported here can be regarded
as highly conservative, as they are based on measurements of total
radioactivity in fish tissues and in water, and do not account for
potential/expected metabolism and expression of radioactivity as
metabolites in tissues. Furthermore, the BCF values are based on dry
wt. of tissue, whereas BCF is typically expressed on a wet wt.,
whole-tissue basis. The fish BCF values are therefore aprroximately
4-fold higher than as would be if reported on wet wt. (whole tissue)
basis. Therefore, DOWFAX 2A1 does not likely exceed the criteria for
high or very high bioaccumulation in aquatic organisms (i.e., BCF >
2,000 and 5,000; respectively). Both LAS and DOWFAX 2A1 posses the
common structural features of sulfonated aromatic ring and C12 alkyl
substituents; therefore, their modes and potential for metabolism in
fish should be equivalent. Both substanes are reported to be miscible in
water. The DOWFAX 2A1 components have slightly higher lipophilicity,
with calculated log Pow (US EPA KOWWIN v.167) ranging from 4.98 to 11.8;
while that for components of LAS range from 4.71 to 5.69.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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