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EC number: 240-008-3 | CAS number: 15876-47-8
Table No. I
Summary of Evaluation of Dermal Reaction
Test System : Sprague Dawley Rat
Sex : Male
Total Number of
Period of signs in days
From - to
No dermal reaction observed
1 - 5
Day 0 - Day 14
Sex : Female
6 - 10
Table No. II
Individual Animal - Evaluation of Dermal Reaction
Sex : Male
Group : I
Dose : 2000 mg/kg body weight
D A Y S
Sex : Female
A study was designed and conducted to determine the dermal reaction profile of Disodium 4-hydroxy-3-[(4-sulphonatonaphthyl)azo] naphthalenesulphonate in Sprague Dawley rats. The study was performed as per OECD Guidelines 402 and complying to the GLP procedures.
The test item was applied to shorn skin of 5 male and 5 female animals at 2000 mg/kg body weight. Administration of the test item at 2000 mg/kg did not result in any skin reaction at the site of application during the study period of 14 days. Administration of the test item did not result in any signs of toxicity and mortality during the study period of 14 days. Animals exhibited normal body weight gain through the study period of 14 days.Gross pathological examination did not reveal any abnormalities attributable to the treatment.From the study, it can be concluded that the test substance ‘Disodium 4-hydroxy-3-[(4-sulphonatonaphthyl)azo] naphthalenesulphonate’ is nonirritant to the skin of Sprague Dawley rats when applied to the shorn skin of 5 male and 5 female animals at the tested dose level of 2000 mg/kg body weight. Also the erythema and edema score of rats was calculated as 0. Thus it can be concluded that the substance Disodium 4-hydroxy-3-[(4-sulphonatonaphthyl)azo] naphthalenesulphonate can be classified under the category "Not Classified".
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