Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 289-200-9
CAS number: 86178-38-3
A LLNA is available on 3,3,5-trimethylcyclohexyl acrylate to evaluate
the skin sensitising potential.
Based on this study, 3,3,5-trimethylcyclohexyl acrylate is considered to
be a skin sensitizer with a EC1.4 of 5.14%.
The test was performed to assess the skin sensitisaition potential of
the test item 3,3,5 -trimethylcyclohexyl acrylate in the CBA/J strain
mouse following topical applications to the dorsal surface of the ear.
Five groups of four animals were treated for three consecutive days (D1,
D2, D3) with 50 µL (25 µL per ear) of the test item undiluted (100%) and
diluted in acetone/olive oil (4:1, v/v) (AOO) at concentrations of 50%,
25%, 10% and 5%. A further group of 4 animals was treated with
acetone/olive oil (4:1, v/v) (AOO).
On D6, the proliferation of lymphocytes in the draining auricular lymph
nodes was determined by cell counting. The experimental protocol was
established according to the OECD test guideline no.429 (2010).
No mortality and no signs of systemic toxicity were noted in the test
and control animals during the test. No significant increases in ear
thickness and in ear weight was noted in animals treated at 5%, 10%,
25%, 50% and 100%. The test item has to be considered as non-irritant at
The stimulation index (SI) calculated by pooled approach was 1.38, 2.09,
3.01, 3.91 and 5.40 for the treated groups at 5%, 10%, 25%, 50% and
100%, respectively. The EC1.4 determined by linear regression was 5.14%.
In conclusion, in view of these results, under these experimental
conditions, the test item 3,3,5 -trimethylcyclohexyl acrylate has to be
classified as a sensitizer.
Based on the available data, 3,3,5 -trimethylcyclohexyl acrylate should
be classified as skin sensitizer (Skin Sens.1B, H317) according to the
Regulation EC n°1272/2008.
Justification: Positive results in the LLNA and EC1.4 > 2%
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again