Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Remarks:
Mathematical simulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Data source

Referenceopen allclose all

Title:
IH SkinPerm (v2.04)
Author:
AIHA
Year:
2018
Bibliographic source:
https://www.aiha.org/get-involved/VolunteerGroups/Pages/Exposure-Assessment-Strategies-Committee.aspx
Reference Type:
publication
Title:
Dermal absorption of chemicals: estimation by IH SkinPerm
Author:
Tibaldi R, ten Berge W, Drolet D
Year:
2014
Bibliographic source:
J Occup Environ Hyg.,11(1):19-31

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
IH SkinPerm mathematical tool for estimating dermal absorption

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,5-trimethylcyclohexyl acrylate
EC Number:
289-200-9
EC Name:
3,3,5-trimethylcyclohexyl acrylate
Cas Number:
86178-38-3
Molecular formula:
C12H20O2
IUPAC Name:
3,3,5-trimethylcyclohexyl prop-2-enoate
Specific details on test material used for the study:
-Molecular weight : 196.29
-Temperature : 25°C
-Vapour pressure : 12.8 Pa (25°C)
-Water solubility = 18.3 mg/L
-Log kow = 4.6
-density = 930 mg/cm2
-melting point = -94.8 °C

Administration / exposure

Details on in vitro test system (if applicable):
Details of the method are available on the attached document.

Results and discussion

Percutaneous absorption
Time point:
8 h
Dose:
100
Parameter:
percentage
Absorption:
0.8 %

Any other information on results incl. tables

Details of the results are available on the attached document.

Applicant's summary and conclusion

Conclusions:
According to the IH skin perm (QSAR), the dermal absorption of 3,3,5-trimethylcyclohexyl acrylate is 0.8%.