Registration Dossier
Registration Dossier
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EC number: 205-840-3 | CAS number: 155-04-4
Carcinogenicity
Administrative data
Description of key information
The carcinogenic potential of ZMBT was evaluated in an early carcinogenicity study (NCI 1968) and was not found to be tumorgenic when given orally to mice for 18 months at the maximal tolerated dose; however the value of the study is limited.
Key value for chemical safety assessment
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
Additional information
The carcinogenic potential of ZMBT was evaluated in an early carcinogenicity study (NCI 1968, Innes 1969). Even through the study was not performed according to present standards, it should be mentioned that ZMBT was not found to be tumorigenic when given orally to mice for 18 months at the maximal tolerated dose, which was fixed at 1000 mg/kg MBT by gavage (dissolved in 0.5 % gelatine) from day 7 to 28 of age and at 3385 ppm (ca. 508 mg/kg bw/day) in the diet from day 28 for additional 17 months.
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