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EC number: 205-840-3 | CAS number: 155-04-4
Males and females administered with [14C] MBT excreted in the urine 96 h after dosing 90.7% and 101% of the radioactivity, respectively. Simularly, 9.99% and 5.22% of the dose, respectively, was excreted in the feces in 96 h. A small portion of the administered radiosctivity (1.20 to 1.53% of dose) remains associated with the erythrocytes at 96 h after dosing. Most of this radioactivity was bound to the erythrocyte membranes.
Half-lives of elimination from the plasma have been calculated to be 4.7 to 8.56 h and 5780 to 6000 h for the alpha and beta phases, respectively.
At 96 h after dosing, only trace amounts of radioactivity remain in other tissues. Of these tissues, thyroid contains the highest concentration. No intact MBT or MBTS was seen in the urine. Only two metabolites appeared in the urine at 8 hours. The major one was a glucuronide derivate of MBT. The other metabolite was not subject to hydrolysis by acid, beta-glucuronidase, or sulfarase, and therefore is probably not a conjugate.
The authors conclude, that radioactivity from [14C] MBT appears to be excreted in a similar manner by male and female rats dosed previously for 14 days with unlabeled MBT. With the exception of whole blood and thyroid, retention of radioactivity from [14C] MBT in tissues is negligible. Excretion is primarily in the urine, with relative small amounts appearing in the feces. Only two metabolites were found in the urine, the major one being a glucuronide derivate of MBT.
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