Registration Dossier

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
transformation / dissolution of metals and inorganic metal compounds
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
equivalent or similar to
Guideline:
OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
Qualifier:
according to
Guideline:
other: UN Transformation/Dissolution Protocol (T/DP) for Metals and Sparingly Soluble Metal Compounds.
GLP compliance:
no
Type of method:
other: Transformation/dissolution
Test material information:
Composition 1
Type of test:
screening transformation/dissolution test - sparingly soluble metal compounds
Mean dissolved conc.:
0.9 µg/L
Element analysed:
ruthenium
Loading of aqueous phase:
100 mg/L
Incubation duration:
24 h
Test conditions:
pH 6
Type of test:
screening transformation/dissolution test - sparingly soluble metal compounds
Mean dissolved conc.:
0.17 µg/L
Element analysed:
ruthenium
Loading of aqueous phase:
100 mg/L
Incubation duration:
24 h
Test conditions:
pH 8.5
Type of test:
full transformation/dissolution test - metals and sparingly soluble metal compounds
Mean dissolved conc.:
0 µg/L
Element analysed:
ruthenium
Loading of aqueous phase:
1 mg/L
Incubation duration:
28 d
Test conditions:
pH 6
Type of test:
full transformation/dissolution test - metals and sparingly soluble metal compounds
Mean dissolved conc.:
0 µg/L
Element analysed:
ruthenium
Loading of aqueous phase:
10 mg/L
Incubation duration:
7 d
Test conditions:
pH 6
Type of test:
full transformation/dissolution test - metals and sparingly soluble metal compounds
Mean dissolved conc.:
0.08 µg/L
Element analysed:
ruthenium
Loading of aqueous phase:
100 mg/L
Incubation duration:
7 d
Test conditions:
pH 6
Details on results:
The 24-hour scoping study for ruthenium (IV) oxide indicate a lack of reactivity, 0.9 and 0.17 µg/L at pH 6 and pH 8.5, respectively. In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings. In the 100 mg/L loadings, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at seven days.
Conclusions:
In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13 ) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.
Executive summary:

Skeaff and Beaudoin (2011) follows a standard test guideline for transformation / dissolution studies and is considered adequate for assessment as a key study for this endpoint.A 24-hour screening study was conducted at pH 6 and pH 8.5, followed by a definitive 28-day study at pH 6 with loading rates of 1, 10 and 100 mg L-1.

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.

Description of key information

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13 ) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.

Key value for chemical safety assessment

Water solubility:
0.1 µg/L
at the temperature of:
22.3 °C

Additional information

Skeaff and Beaudoin (2011) follows a standard test guideline for transformation / dissolution studies and is considered adequate for assessment as a key study for this endpoint. A 24-hour screening study was conducted at pH 6 and pH 8.5, followed by a definitive 28-day study at pH 6 with loading rates of 1, 10 and 100 mg L-1.

In the definitive tests at pH 6, there were no net concentration changes for ruthenium (IV) oxide in the 1 and 10 mg/L loadings, after 28 and 7 days respectively. In the 100 mg/L loading, the net concentration of Ru increased to ~0.10 µg/L (σ % = 13) at 6 hours, before declining slightly to 0.08 µg/L at 7 days.