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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1998
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline followed
Principles of method if other than guideline:
Only handbook or published data available. No guideline indicated.
GLP compliance:
not specified
Test type:
other: not indicated
Species:
mouse
Strain:
not specified
Sex:
male/female
Route of administration:
oral: unspecified
Vehicle:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 190 mg/kg bw
Based on:
test mat.
Remarks:
Li2SO4
Remarks on result:
other: Walum et al.
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
953 mg/kg bw
Based on:
test mat.
Remarks:
Li2SO4
95% CL:
> 822 - <= 1 103
Remarks on result:
other: Samoilov et al.
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Both publications state a LD50 of around 1000 mg/kg bw. Walum (1998) specifies a LD50 of 1190 mg/kg bw and Samoilov et al. (1970) a LD50 of 853 mg/kg bw for male and female albino mice.
Executive summary:

Both publications state a LD50 of around 1000 mg/kg bw. Walum (1998) specifies a LD50 of 1190 mg/kg bw and Samoilov et al. (1970) a LD50 of 853 mg/kg bw for male and female albino mice.

Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Type of study / information:
Acute oral toxicity to humans
Endpoint addressed:
acute toxicity: oral
Qualifier:
no guideline followed
Principles of method if other than guideline:
Only handbook or published data available. No guideline indicated.
GLP compliance:
not specified
Results:
The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans.
Conclusions:
The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans.
Executive summary:

The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans. The value was obtained from clinical and/or autopsy data from the Swedish Poison Information Centre.

Data source

Reference
Reference Type:
review article or handbook
Title:
Acute Oral Toxicity
Author:
Walum, E.
Year:
1998
Bibliographic source:
Environ. l Health Persp. 106, Suppl. 2, 497, 1998

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Only handbook or published data available. No guideline indicated.
GLP compliance:
not specified
Test type:
other: not indicated

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium sulphate
EC Number:
233-820-4
EC Name:
Lithium sulphate
Cas Number:
10377-48-7
Molecular formula:
H2O4S.2Li
IUPAC Name:
dilithium sulfate
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
613 mg/kg bw
Based on:
test mat.
Remarks:
Li2SO4

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The publication of Walum et al. states a LD50 value of 613 mg/kg bw for rats.
Executive summary:

The publication was used to analyse the predictive power of animal tests for human toxicity. The Scandinavian Society of Cell Toxicology used lithium sulfate as one out of 50 reference substances. The LD50 value for rats was determined out of several studies and defined as 613 mg/kg bw.