Trilithium orthophosphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1998

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

Only handbook or published data available. No guideline indicated.

GLP compliance:

not specified

Test type:

other: not indicated

Species:

mouse

Strain:

not specified

Sex:

male/female

Route of administration:

oral: unspecified

Vehicle:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 190 mg/kg bw

Based on:

test mat.

Remarks:

Li2SO4

Remarks on result:

other: Walum et al.

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

953 mg/kg bw

Based on:

test mat.

Remarks:

Li2SO4

95% CL:

> 822 - <= 1 103

Remarks on result:

other: Samoilov et al.

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Both publications state a LD50 of around 1000 mg/kg bw. Walum (1998) specifies a LD50 of 1190 mg/kg bw and Samoilov et al. (1970) a LD50 of 853 mg/kg bw for male and female albino mice.

Executive summary:

Both publications state a LD50 of around 1000 mg/kg bw. Walum (1998) specifies a LD50 of 1190 mg/kg bw and Samoilov et al. (1970) a LD50 of 853 mg/kg bw for male and female albino mice.

Cross-reference 2

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Type of study / information:

Acute oral toxicity to humans

Endpoint addressed:

acute toxicity: oral

Qualifier:

no guideline followed

Principles of method if other than guideline:

Only handbook or published data available. No guideline indicated.

GLP compliance:

not specified

Results:

The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans.

Conclusions:

The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans.

Executive summary:

The publication of Walum et al. (1998) states a mean oral lethal dose of 1065 mg/kg bw for humans. The value was obtained from clinical and/or autopsy data from the Swedish Poison Information Centre.

Data source

Reference

Reference Type:

review article or handbook

Title:

Acute Oral Toxicity

Author:

Walum, E.

Year:

1998

Bibliographic source:

Environ. l Health Persp. 106, Suppl. 2, 497, 1998

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Only handbook or published data available. No guideline indicated.

GLP compliance:

not specified

Test type:

other: not indicated

Test material

Test material information

Constituent 1

Reference substance name:

Lithium sulphate

EC Number:

233-820-4

EC Name:

Lithium sulphate

Cas Number:

10377-48-7

Molecular formula:

H2O4S.2Li

IUPAC Name:

dilithium sulfate

Test material form:

solid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

613 mg/kg bw

Based on:

test mat.

Remarks:

Li2SO4

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The publication of Walum et al. states a LD50 value of 613 mg/kg bw for rats.

Executive summary:

The publication was used to analyse the predictive power of animal tests for human toxicity. The Scandinavian Society of Cell Toxicology used lithium sulfate as one out of 50 reference substances. The LD50 value for rats was determined out of several studies and defined as 613 mg/kg bw.