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EC number: 601-017-1 | CAS number: 110964-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- EC Number:
- 601-017-1
- Cas Number:
- 110964-79-9
- Molecular formula:
- C8 H7 N1 O6 S1
- IUPAC Name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): 2-Nitro-4-methylsulfonyl benzoic acid (MNBA)
- Physical state: Solid
- Analytical purity: 97 % (w/w)
- Lot/batch No.: 15483-30-1
- Storage condition of test material: Ambient temperature in darkness
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: treated: left eye; unterated (control): right eye
- Amount / concentration applied:
- 1OOmg/eye/animal
- Duration of treatment / exposure:
- treatment without rinsing
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: # 13
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 2 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: # 7
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 3 d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: # 8, 9, 10 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0
- Reversibility:
- other: no signs of irritation (cornea) at any time
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: # 11
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 3 d
- Irritation parameter:
- iris score
- Basis:
- animal: # 13, 7, 8, 11 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.7
- Reversibility:
- fully reversible within: 3 d
- Irritation parameter:
- iris score
- Basis:
- animal: # 9
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 2 d
- Irritation parameter:
- iris score
- Basis:
- animal: # 10
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 4
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: # 13, 8, 9, 10 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 2
- Reversibility:
- fully reversible within: 14 - 21 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: # 7
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 3
- Reversibility:
- fully reversible within: 11 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: # 11
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 2.7
- Reversibility:
- fully reversible within: 21 d
- Irritation parameter:
- chemosis score
- Basis:
- animal: # 13 and 11 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 2.3
- Reversibility:
- fully reversible within: 10 - 14 d
- Irritation parameter:
- chemosis score
- Basis:
- animal: # 7, 9, 10 each
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 2
- Reversibility:
- fully reversible within: 7 - 11 d
- Irritation parameter:
- chemosis score
- Basis:
- animal: # 8
- Time point:
- other: mean of 24, 48, 72 h
- Score:
- 1.7
- Reversibility:
- fully reversible within: 4 d
- Irritant / corrosive response data:
- Additional signs of irritation included erythematous, thickened and convoluted eyelids, mucoid discharge and haemorrhage of the nictitating membrane. Some animals held their dosed eye closed which may be indicative of pain.
All signs of irritation were fully reversible within 21 days. - Other effects:
- No other effects were reported.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- MNBA was irritant to the rabbit eye.
- Executive summary:
2-Nitro-4-methylsulfonyl benzoic acid (MNBA) was applied into one eye of each of six rabbits and an assessment of initial pain was made. The eyes were examined for up to 21 days, to assess the grade of ocular reaction.
Application into the eye caused slight initial pain.
Slight corneal opacity and iritis were observed, and had completely regressed 4 days after application. Conjunctival effects, consisting of slight to severe redness, chemosis and discharge in all animals, had completely regressed 21 days after application.
MNBA was irritant to the rabbit eye.
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