Registration Dossier
Registration Dossier
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EC number: 601-017-1 | CAS number: 110964-79-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-01-10 to 1996-01-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD and GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- EC Number:
- 601-017-1
- Cas Number:
- 110964-79-9
- Molecular formula:
- C8 H7 N1 O6 S1
- IUPAC Name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): 2-Nitro-4-methylsulfonyl benzoic acid (MNBA)
- Physical state: Solid
- Analytical purity: 97 % (w/w)
- Lot/batch No.: 15483-30-1
- Storage condition of test material: Ambient temperature in darkness
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk: APfSD (Wistar-derived)
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: deionised water
- Duration of exposure:
- 24h
- Doses:
- a single limit dose-level of 2000mg/kg was administered
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died.
- Clinical signs:
- other: There were no significant signs of toxicity and practically no signs of skin irritation.
- Gross pathology:
- There were no macroscopic abnormalities at post mortem examination.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The acute dermal median lethal dose of MNBA was in excess of 2000mg/kg to male and female rats.
- Executive summary:
A group of five male and five female Alpk: APfSD (Wistar-derived) rats received a single dermal application of 2000 mg/kg of 2-nitro-4-methylsulfonyl benzoic acid (MNBA). The animals were assessed daily for the following 14 days for any signs of systemic toxicity and their bodyweights were recorded at intervals throughout the study. At the end of the study all the animals were killed and subjected to a macroscopic examination post mortem.
Following a single dermal application of 2000mg/kg of the test sample, none of the animals died. There were no significant signs of toxicity and practically no signs of skin irritation. All animals had exceeded their initial bodyweight by the end of the study.
The acute dermal median lethal dose of MNBA was in excess of 2000mg/kg to male and female rats.
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