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Diss Factsheets
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EC number: 910-356-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “read-across: supporting information”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- copper
- Basis for effect:
- mobility
- Remarks on result:
- other: measured dissolved copper concentration was ca. 0.3 mg/L; equal result obtained based on dissolved copper fraction of 0.18% for nominal CuO concentration at pH 7-8 (see section 6.1.5, Aruoja et al. 2009)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 732 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: value recalculated based on the ratio of MnO2 and CuO in the reaction mass
- Validity criteria fulfilled:
- not specified
- Remarks:
- details not given in the publication
- Conclusions:
- The determined 48h-EC50 (Daphnia magna, immobility) was 732 mg/L (nominal), corresponding to 0.3 mg/L dissolved copper (measured).
- Executive summary:
The study used as source reference investigated the toxicity of nano-sized and bulk metal oxides ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus. The bulk form of each metal oxide was used to compare toxic effects between nano and bulk form. The study results of the source compound were considered applicable for the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the attached document (see section 13 or find a link in cross reference).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint specific justification please see read-across report in section 13 or find a link in cross-reference “assessment report”.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- assessment report
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 143 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: value recalculated based on the ratio of MnO2 and CuO in the reaction mass
- Validity criteria fulfilled:
- yes
- Conclusions:
- The derived 48h-EC50 (Daphnia magna, mobility) > 143 mg/L (limit test, 100% (v/v) saturated solution prepared at 100 mg/L test item); no toxic effects were observed.
- Executive summary:
The study used as source investigated short-term toxicity to aquatic invertebrates acc. to OECD 202. The study results of the source compound were considered applicable to the target compound and were used for classification and labelling acc. to REGULATION (EC) No 1272/2008. Justification and applicability of the read-across approach (structural analogue) is outlined in the read-across report in section 13 or find a link in cross reference “assessment report”.
Referenceopen allclose all
Description of key information
48h-EC50 (Daphnia magna, immobilisation) = 732 mg/L (nominal, total fraction, submission substance), corresponding to 0.3 mg/L dissolved copper (measured) (OECD 202)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.3 mg/L
Additional information
Two reliable key studies were available for the hazard assessment of short-term toxicity to aquatic invertebrates for the submission substance reaction mass of copper oxide and manganese dioxide.
One of the key studies investigated the short-term toxicity of manganese dioxide to aquatic invertebrates, conducted under GLP conditions and in accordance with OECD 202 and EU Method C.2. As the test material was considered to be of very low water solubility, the study was conducted with a saturated solution of test material. No daphnia immobilisation was observed over the 48-hour test period. The 48-hour EC50 was therefore determined to be greater than 100% (v/v) saturated solution. The study showed that there were no toxic effects at the limit of solubility of the test material in the test medium. The derived 48h-EC50 for the submission substance was > 143 mg/L (recalculated based on the ratio of MnO2 and CuO in the reaction mass).
The second key study investigated the acute toxicity of copper oxide to Daphnia magna (RL2, 2008). The study was carried out using DAPHTOXKIT F™ according to OECD 202. The study was conducted with five test concentrations, a blank control and positive control (copper sulfate) were run in parallel. Immobilisation of daphnia magna occurred in a dose-response relationship; i.e. increasing immobilisation with increasing copper oxide concentration. The derived nominal EC50 for the submission substance was 732 mg/L (recalculated based on the ratio of MnO2 and CuO in the reaction mass), corrsponding to 0.3 mg/L dissolved copper (measured).
As copper oxide was the toxic constituent of the submission substance, the key value for the environmental hazard assessment of the reaction mass of copper oxide and manganese dioxide was based on the derived effect concentration of copper oxide.
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