Registration Dossier
Registration Dossier
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EC number: 419-040-9 | CAS number: 89604-92-2 TAEM
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.6 (Bühler-Test)
- GLP compliance:
- yes
- Type of study:
- other: Traditional sensitisation test
- Justification for non-LLNA method:
- Traditional sensitisation test
Test material
- Reference substance name:
- 2-mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
- EC Number:
- 419-040-9
- EC Name:
- 2-mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
- Cas Number:
- 89604-92-2
- Molecular formula:
- C20H22N4O4S3
- IUPAC Name:
- tert-butyl 2-{[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino]oxy}-2-methylpropanoate
Constituent 1
In vivo test system
Test animals
- Species:
- other: gpg
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: not available
- Vehicle:
- petrolatum
- Concentration / amount:
- 40%
Challenge
- Route:
- other: n.a.
- Vehicle:
- petrolatum
- Concentration / amount:
- 40%
- No. of animals per dose:
- Number of animals in test group: 20
Number of animals in negative control group: 10
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 40%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 40%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 40%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 40%
- No. with + reactions:
- 0
- Total no. in group:
- 10
Any other information on results incl. tables
Maximum concentration not causing irritating effects in preliminary test: 40 %
Signs of irritation during induction:
keine
"ENGLISH"
none
Evidence of sensitisation of each challenge concentration:
keine
"ENGLISH"
none
Other observations:
keine
"ENGLISH"
none
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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