Registration Dossier
Registration Dossier
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EC number: 943-697-5 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- intraperitoneal
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The test was conducted by means of Read Across approach. Further information was attached at section 13
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- - Principle of test: determination of the approximate lethal dose.
- Observation period: 7 days
- Parameters analysed / observed: mortality, gross pathology. - GLP compliance:
- no
- Remarks:
- Pre 1981
Test material
- Reference substance name:
- Similar Substance 01 - ABr165:1
- IUPAC Name:
- Similar Substance 01 - ABr165:1
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 2 to 30 % solution
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 350 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Deaths occurred.
- Clinical signs:
- Animals in staggering abdominal position; brown discoloration of all visible parts of the skin.
- Gross pathology:
- Internal organs, abdominal serous membranes and soft tissue stained brown .
Applicant's summary and conclusion
- Conclusions:
- LD50 (intraperitoneal) = 350 mg/kb b.w.
- Executive summary:
Mice were exposed to a single intraperitoneal administration of the test substance, which resulted to be moderately toxic, with a LD50 of 350 mg/kg b.w.
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