Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-648-2 | CAS number: 2491-06-7
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491 -06 -7). The bioconcentration factor (BCF) of 2-(dimethylamino)acetic acid hydrochloride was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2-(dimethylamino)acetic acid hydrochloride is not expected to bioaccumulate in the food chain.
Additional information
Bioaccumulation: aquatic / sediment
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491 -06 -7). The bioconcentration factor (BCF) of 2-(dimethylamino)acetic acid hydrochloride was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 2-(dimethylamino)acetic acid hydrochloride is not expected to bioaccumulate in the food chain.
In another predicted report from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for 2-(dimethylamino)acetic acid hydrochloride was estimated to be 4.15 dimensionless. The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 2-(dimethylamino)acetic acid hydrochloride is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (HSDB, 2017) for the read across chemical bioaccumulation experiment was conducted. Bioaccumulation study was conducted for estimating the Bioaccumulation value (BCF) of test chemical 3-(N',N' dimethylhydrazinecarbonyl) propanoic acid (CAS no. 1596 -84 -5). The Bioaccumulation value (BCF) value was calculated using a log Kow of -1.5 and structure estimation method based on regression-derived equation. Bioaccumulation value (BCF) of 3-(N',N'-dimethylhydrazinecarbonyl)propanoic acid was estimated to be 3 which does not exceed the bio concentration threshold of 2000, indicating that the chemical 3-(N',N'-dimethylhydrazine carbonyl)propanoic acid is not expected to bioaccumulate in the food chain.
On the basis of available information, the test 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491-06-7) can be considered to be nonbioaccumulative in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
