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EC number: 219-648-2 | CAS number: 2491-06-7
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of 2-(dimethylamino) acetic acid hydrochloride (CAS no. 2491 -06 -7) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 76 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 2-(dimethylamino)acetic acid hydrochloride was estimated to be readily biodegradable in water.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491 -06 -7). If released in to the environment, 33.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 2-(dimethylamino)acetic acid hydrochloride in water is estimated to be 1.11 days (26.8 hrs.). The half-life (1.11 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 2-(dimethylamino)acetic acid hydrochloride in sediment is estimated to be 77.91 days (1870 hrs.). Thus half-life (77.91 days estimated by EPI suite) indicates that the chemical is not persistent in water as well as sediment.
Biodegradation in soil:
The half-life period of 2-(dimethylamino)acetic acid hydrochloride (CAS No.2491 -06 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 66.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-(dimethylamino)acetic acid hydrochloride in soil is estimated to be 17.33 days (416 hrs). Based on this half-life value of 2-(dimethylamino) acetic acid hydrochloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Additional information
Biodegradation in water:
Various predicted data for the target compound 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491-06-7) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 2-(dimethylamino) acetic acid hydrochloride was estimated. Biodegradability of 2-(dimethylamino) acetic acid hydrochloride (CAS no. 2491 -06 -7) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 76 % degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 2-(dimethylamino)acetic acid hydrochloride was estimated to be readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 2-(dimethylamino)acetic acid hydrochloride (CAS no. 2491 -06 -7) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical 2-(dimethylamino)acetic acid hydrochloride is expected to be readily biodegradable.
In a supporting weight of evidence study from peer reviewed journal for RA CAS acetic acid (64-19-7) The test chemical acetic acid was tested for % biodegradation for 7 days at 30 mgC/l concentration by analyzing the decrease of DOC taking benzoic acid as a reference (standard) compound using inoculum obtained from synthetic sewage at concentration of 100 mgC/l using JIS BOD5inorganic medium for 7 days in anaerobic condition 99% biodegradation ratio was obtained. So it is concluded that this test compound is readily biodegradable.
In a supporting weight of evidence study from authoritative databases for RA CAS 144-62-7 (acide oxalique), Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance acide oxalique (CAS no. 144-62-7). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 37, 100 and 100% by BOD, TOC, and HPLC parameter in 14 days. Thus, based on percentage degradation, acide oxalique is considered to be readily biodegradable in water.
On the basis of above results for target chemical 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491-06-7) (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance authoritative from database J-CHECK, and peer reviewed journal it can be concluded that the test substance 2-(dimethylamino)acetic acid hydrochloride can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 2-(dimethylamino)acetic acid hydrochloride (CAS No. 2491 -06 -7). If released in to the environment, 33.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 2-(dimethylamino)acetic acid hydrochloride in water is estimated to be 1.11 days (26.8 hrs.). The half-life (1.11 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 2-(dimethylamino)acetic acid hydrochloride in sediment is estimated to be 77.91 days (1870 hrs.). Thus half-life (77.91 days estimated by EPI suite) indicates that the chemical is not persistent in water as well as sediment.
Biodegradation in soil:
The half-life period of 2-(dimethylamino)acetic acid hydrochloride (CAS No.2491 -06 -7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 66.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 2-(dimethylamino)acetic acid hydrochloride in soil is estimated to be 17.33 days (416 hrs). Based on this half-life value of 2-(dimethylamino) acetic acid hydrochloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
On the basis of available information, the test 2-(dimethylamino)acetic acid hydrochloride (CAS No.2491 -06 -7) can be considered to be readily biodegradable in nature.
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