Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-216-9 | CAS number: 13241-33-3
A pharmacokinetic study was performed after a single oral administration of Poncirus trifoliata extract to 6 male Sprague-Dawley rats, containing 0.604 mg/mL of neohesperidin, which resulted in a dose of 6.04 mg/kg bw of neohesperidin. Neohesperidin content was determined in rat plasma by means of a validated UHPLC-MS/MS method. The substance was quickly absorbed and found in plasma 5 minutes after oral administration. The relevant toxicokinetic parameters obtained were the following: The time of maximum plasma concentration (Tmax) and maximum plasma concentration (Cmax) were 1.18 ± 0.57 h and 19.1 ± 3.6 ng/mL, the half-life of elimination (T1/2) was 4.17 ± 1.04 h, and the area under the curve to the last measurable concentration (AUC0–t) and to infinity (AUC) were 79.2 and 94.8 mg/Lh.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again