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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
3-Hydroxy-2-naphthalin-carbonsäure [MAK Value Documentation in German language, 2006]
Author:
The MAK Collection for Occupational Health and Safety
Year:
2012
Bibliographic source:
3-Hydroxy-2-naphthalin-carbonsäure [MAK Value Documentation in German language, 2006]. The MAK Collection for Occupational Health and Safety. 1–9. 2012.
Reference Type:
secondary source
Title:
SIDS Report of 3-Hydroxy-2-naphthoic acid
Author:
OECD SIDS
Year:
2004
Bibliographic source:
OECD SIDS; SIDS Initial Assessment Report For SIAM 19 Berlin, Germany; 19-22 October 2004

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
An ocular irritation test of 3-hydroxynaphthalene-2-carboxylic acid (CAS No: 92-70-6) was conducted on rabbits to assess its irritation potential in accordance with OECD Guide-line 405 "Acute Eye Irritation/Corrosion".
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report):3-Hydroxy-2-naphthoic acid
- Molecular formula:C11H8O3
- Molecular weight :188.1812 g/mol
- Substance type:Organic
- Physical state:Solid
-Smiles: c12c(cc(c(c1)C(=O)O)O)cccc2
-InChI: 1S/C11H8O3/c12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h1-6,12H,(H,13,14)
Specific details on test material used for the study:
- Name of test material (as cited in study report):3-Hydroxy-2-naphthoic acid
- Molecular formula:C11H8O3
- Molecular weight :188.1812 g/mol
- Substance type:Organic
- Physical state:Solid
-Smiles: c12c(cc(c(c1)C(=O)O)O)cccc2
-InChI: 1S/C11H8O3/c12-10-6-8-4-2-1-3-7(8)5-9(10)11(13)14/h1-6,12H,(H,13,14)

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
other: polyethylene glycol 400
Controls:
not specified
Amount / concentration applied:
100mg (0.5ml)
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
after 1, 24, 48, 72 hours and on day 7 and 14 after application
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): eyes were rinsed off after 24 hours
SCORING SYSTEM: Driaze method

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24/72 h
Score:
1.1
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24/72 h
Score:
0.2
Max. score:
2
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24/72 h
Score:
1.9
Max. score:
3
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritation parameter:
other: conjunctival swelling
Basis:
mean
Time point:
other: 24/72 h
Score:
1.3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
1 hour after application, swelling and conjunctival injections as well as secretion (clear, tinted by the test substance) were observed in all animals. At 24, 48 and 72 hours, conjunctivitis and diffuse corneal opacities were found. One animal showed iritis at 24 and 48 hours. 7 days after the application, corneal vascularization was observed in all animals. The chemical may serious eye damage

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The test material 3-hydroxynaphthalene-2-carboxylic acid (CAS No: 92-70-6) was considered to be irritating to rabbits’ eye with the risk of serious eye damage.
Executive summary:

An ocular irritation test of 3-hydroxynaphthalene-2-carboxylic acid (CAS No: 92-70-6) was conducted on rabbits to assess its irritation potential in accordance with OECD Guide-line 405 "Acute Eye Irritation/Corrosion".

 

During the test, about 100mg of (0.1ml) of chemical was was moistened with Polyethylene Glycol 400 was installed into the eye of each of three rabbits for 24 hours and later eyes were rinsed.

 

Theeyes were examined after 1, 24, 48, 72 hours and on day 7 and 14 after application according to Driaze method.One hour after application, swelling and conjunctival injections as well as secretion (clear, tinted by the test substance) were observed in all animals. At 24, 48 and 72 hours, conjunctivitis and diffuse corneal opacities were found. One animal showed iritis at 24 and 48 hours. 7 days after the application, corneal vascularization was observed in all animals.

 

The Draize score was 1.1 out of a maximum of 4 for corneal opacity, 0.2 out of 2 for iritis, 1.9 out of 3 for conjunctivitis, and 1.3 out of 4 for conjunctival curling.

 

Therefore on the basis of observations and mean scores, the chemical3-hydroxynaphthalene-2-carboxylic acid (CAS No: 92-70-6)was considered to be irritating to rabbits’ eye with the risk of serious eye damage.