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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritive database

Data source

Reference
Reference Type:
other: Authoritive database
Title:
Skin irritation test for Quinoline (CAS no: 91-22-5)
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Skin irritation study of Quinoline (CAS no: 91-22-5) was conducted on clipped rabbits to determine its potential of causing skin irritation.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report):Quinoline
- Molecular formula:C9H7N
- Molecular weight :129.16 g/mol
- Substance type:Organic
- Physical state:Liquid
-Smiles: c12c(cccc1)nccc2
-InChI: 1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H
Specific details on test material used for the study:
- Name of test material (as cited in study report):Quinoline
- Molecular formula:C9H7N
- Molecular weight :129.16 g/mol
- Substance type:Organic
- Physical state:Liquid
-Smiles: c12c(cccc1)nccc2
-InChI: 1S/C9H7N/c1-2-6-9-8(4-1)5-3-7-10-9/h1-7H

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
10
Max. score:
4
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Slight reddening was observed in treated rabbits.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The test material Quinoline (CAS no: 91-22-5) was considered to be mildly irritating to the rabbits skin.
Executive summary:

Skin irritation study of Quinoline (CAS no: 91-22-5) was conducted on rabbits to determine its potential of causing skin irritation.

 

The chemical produced slight reddening after 24 hours when applied dermally. The resulted score was 4 out of maximum possible score of 10.

 

Therefore on the basis of observations, the chemical Quinoline (CAS no: 91-22-5)was considered to be mildly irritating to the rabbits skin.