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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 1-Chloro-4-nitrobenzene (100-00-5)
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Reference Type:
secondary source
Title:
NTP Technical Report on Toxicity Studies of 2-Chloronitrobenzene and 4-Chloronitrobenzene (CAS Nos. 88-73-3 and 100-00-5)
Author:
National Toxicology Program
Year:
1993
Bibliographic source:
National Institutes of Health, National Toxicology Program Toxicity Report Series Number 33, NIH Publication 93-3382, July 1993

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute dermal toxicity study of 1-Chloro-4-nitrobenzene (100-00-5) in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 1-Chloro-4-nitrobenzene
- Common Name: 4-Chloronitrobenzene
- Mol. formula: C6H4ClNO2
- Molecular Weight: 157.556 g/mole
- Smiles: c1([N+](=O)[O-])ccc(Cl)cc1
- InChI: 1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H

Specific details on test material used for the study:
- IUPAC Name: 1-Chloro-4-nitrobenzene
- Common Name: 4-Chloronitrobenzene
- Mol. formula: C6H4ClNO2
- Molecular Weight: 157.556 g/mole
- Smiles: c1([N+](=O)[O-])ccc(Cl)cc1
- InChI: 1S/C6H4ClNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
3040 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 040 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed at 3040 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be 3040 mg/kg bw, when rabbits were treated with 1-Chloro-4-nitrobenzene by dermal application.
Executive summary:

Acute dermal toxicity study was done in rabbits using 1-Chloro-4-nitrobenzene. 50% mortality was observed at dose 3040mg/kg bw. Hence, the LD50 value was considered to be 3040 mg/kg bw, when rabbits were treated with 1-Chloro-4-nitrobenzene by dermal application.