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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) in rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
Reference Type:
secondary source
Title:
Acute oral toxicity study of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) in rat.
Author:
RTECS
Year:
2017
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2017.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2)in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine
- Common Name: Propazine
- Mol. formula: C9H16ClN5
- Molecular Weight: 229.713 g/mole
- Smiles: c1(nc(nc(n1)Cl)NC(C)C)NC(C)C
- InChI: 1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15)

Specific details on test material used for the study:
- IUPAC Name: 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine
- Common Name: Propazine
- Mol. formula: C9H16ClN5
- Molecular Weight: 229.713 g/mole
- Smiles: c1(nc(nc(n1)Cl)NC(C)C)NC(C)C
- InChI: 1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15)

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
3840 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 840 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed.
Mortality:
50% mortality was observed at 3840 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 3840 mg/kg bw, when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.
Executive summary:

The acute oral toxicity study was conducted by using 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazinein rat in the concentration of 3840 mg/kg bw orally. 50% mortality was observed at 3840 mg/kg bw. Therefore, LD50 was considered to be 3840 mg/kg bw, when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.