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Environmental fate & pathways

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Description of key information

Biodegradation in water:

Biodegradability of 3 -Bromoquinoline (CAS no. 5332 -24 -1) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 0.222% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 3 -Bromoquinoline was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment:

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-bromoquinoline (CAS No. 5332 -24 -1).If released in to the environment, 16.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-bromoquinoline in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 3% (i.e, reported as 2.31 %), indicates that 3-bromoquinoline is not persistent in sediment.

 

Biodegradation in soil:

The half-life period of 3-bromoquinoline (CAS No. 5332 -24 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-bromoquinoline in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 3-bromoquinoline, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.

Additional information

Biodegradation in water:

Various predicted data for the target compound 3-Bromoquinoline (CAS No. 5332-24-1) and supporting weight of evidence studies for its closest read across substance with log Kow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 3-Bromoquinoline was estimated. Biodegradability of 3 -Bromoquinoline (CAS no. 5332 -24 -1) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor. Test substance undergoes 0.222% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 3 -Bromoquinoline was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 3-Bromoquinoline in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that the test chemical 3-Bromoquinoline is expected not readily biodegradable.

 

In a supporting weight of evidence study from authoritative databases for RA cas 1- Azanaphthalene-8-ol (CAS no. 148-24-3). Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 1- Azanaphthalene-8-ol (CAS no. 148-24-3). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD, TOC, and HPLC parameter in 28 days. Thus, based on percentage degradation, 1-Azanaphthalene-8-ol is considered to be not readily biodegradable in water.

 

Another biodegradation study (from authoritative database J-CHECK, 2017), Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance 1-hydroxy-9,10 -dihydroanthracene-9,10-dione (129-43-1) Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 2 % by BOD, 1% by HPLC parameter in 28 days. Thus, based on percentage degradation, 1-hydroxy-9,10-dihydroanthracene-9,10-dione is considered to be not readily biodegradable in water.

 

On the basis of above results for target chemical 3-Bromoquinoline (CAS No. 5332-24-1) (from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance authoritative from database J-CHECK, it can be concluded that the test substance 3-Bromoquinoline can be expected to be not readily biodegradable in nature.

 

 

Biodegradation in water and sediment:

 

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 3-bromoquinoline (CAS No. 5332 -24 -1).If released in to the environment, 16.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 3-bromoquinoline in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of test chemical in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 3% (i.e, reported as 2.31 %), indicates that 3-bromoquinoline is not persistent in sediment.

 

Biodegradation in soil:

The half-life period of 3-bromoquinoline (CAS No. 5332 -24 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 3-bromoquinoline in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of 3-bromoquinoline, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.

 

On the basis of available information, the test 3-bromoquinoline (CAS No. 5332 -24 -1) can be considered to be not readily biodegradable in nature.