5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From August 11th to August 17th, 2016.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Deviations:

no

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Key result

Percentile:

D10

Mean:

0.95 µm

St. dev.:

0.3

Key result

Percentile:

D50

Mean:

18.52 µm

St. dev.:

0.3

Key result

Percentile:

D90

Mean:

84.15 µm

St. dev.:

0.3

Key result

Percentile:

other: D4,3

Mean:

32.55 µm

St. dev.:

0.3

Remarks on result:

other: Mass moment mean (De Brouckere Mean Diameter)

 Table 1. Results of particle size distribution.

Particle size [µm]	1	2	3	4	5	Average
d10	0.96	0.95	0.95	0.94	0.94	0.95
d50	18.86	18.59	18.71	18.20	18.25	18.52
d90	84.66	84.38	83.63	83.66	84.42	84.15
* d4,3, [µm]	32.94	32.50	32.75	32.25	32.29	32.55
Average d43, [µm]	32.55
Standard deviation, [µm]	0.30
Relative Standard Deviation, [%]	0.92

* Average d43, [µm] – The mass moment mean (De Brouckere Mean Diameter)

Conclusions:

The average particle size results for the test item are: D10 = 0.95 µm, D50 = 18.52 µm, D90 = 84.15 µm, D4,3 = 32.55 µm.

Executive summary:

The particle size distribution for the test substance was determined according to OECD 110 / CIPAC MT 187 - Particle size analysis by laser diffraction / ISO 13320 -1 (GLP study). The average particle size results for the test item are: D10 = 0.95 µm, D50 = 18.52 µm, D90 = 84.15 µm, D4,3 = 32.55 µm.

Description of key information

Key study. Method according to OECD 110 / CIPAC MT 187 / ISO 13320 -1, GLP study. The average particle size results for the test item are: D10 = 0.95 µm, D50 = 18.52 µm, D90 = 84.15 µm, D4,3 = 32.55 µm.

Additional information

Key study. The particle size distribution for the test substance was determined according to OECD 110 / CIPAC MT 187 - Particle size analysis by laser diffraction / ISO 13320 -1 (GLP study). The average particle size results for the test item are: D10 = 0.95 µm, D50 = 18.52 µm, D90 = 84.15 µm, D4,3 = 32.55 µm.