Registration Dossier
Registration Dossier
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EC number: 815-305-1 | CAS number: 138938-64-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Bacterial reverse mutation assay: the substance 1-[(1,1-Dimethylethyl)dimethylsilyl]piperazine was negative with and without metabolic activation in S. typhimurium strains TA 98, TA100, TA1535, TA1537 and E.coli WP2uvrA (OECD TG 471) (Ceri Hita, 2012).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
1-(Tert-butyldimethylsilyl)piperazine has been tested in a valid Bacterial reverse mutation assay, conducted according to a protocol similar to OECD TG 471, and in compliance with GLP, using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and E.coli WP2uvrA. No increase in the number of revertants was observed in any test strain, with or without metabolic activation when tested up to a limit concentration. Appropriate positive and negative (solvent) controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
Justification for classification or non-classification
Based on the available data for 1-(tert-butyldimethylsilyl)piperazine, no classification is required for genetic toxicity according to Regulation (EC) No 1272/2008.
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