Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Biodegradation in water screening tests: 1% (DOC) biodegradation in 28 days (OECD 301C). No significant biodegradation is expected for the silanol hydrolysis product

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

The key study is the only biodegradation study available for the substance. In a test conducted in accordance with OECD 301C (Modified MITI Test) and in compliance with GLP, the test substance attained 1% (DOC) degradation in 28 days.


1-(tert-butyldimethylsilyl)piperazine hydrolyses within the timescale of the ready biodegradation study to form tert-butyldimethylsilanol and piperazine.


Piperazine was reported as not readily biodegradable but inherently biodegradable (OECD 2004).


No significant biodegradation is expected for the silanol hydrolysis products.




OECD (2004). SIDS Initial Assessment Profile, Piperazine, CAS No. 110-85-0. SIAM 18, 20-23 April 2004