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EC number: 946-324-4 | CAS number: -
This approach uses a thermodynamically based module to calculate the water concentrations and the individual toxicity of each of the constituent is first derived from a QSAR model validated to be compliant with the OECD recommandations for QSAR modeling (OECD, 2004). Then the effective loading rate of the mixture to the test organisms (i.e. fish) is determined as a Water Accommodated Fraction (WAF) test (OECD, 2000).
The inputs into the model all came from reliable QSAR estimations. The endpoint value is considered valid for use in risk assessment (including PBT assessment) and classification and labelling. The prediction is adequate as contributing data for the Classification and Labelling or risk assessment of the substance as indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3.
The 96 hour LL50 for the test substance was estimated to be 5.8 mg/L.
Constituent 1: 96h Lc50 = 0.46 mg/L; REACH guidance on QSARs R.6, OECD Guideline 203 (Fish, Acute Toxicity Test), with modifications from OECD Series on Testing and Assessment no. 23 on ecotoxicity testing of difficult substances (Anon., 2017).
Ecotox endpoints and expected concentrations of each constituent in the mixture (based on % composistion w/w)
Concentration in the WAF
(4R)-4-(2-methoxy-2-propanyl)-1-methylcyclohexene (ether MT)
aindividual reports for each constituent presented in Section 6.1.1
The 96h LC50 for constituent 1 = 0.46 mg/L is used for chemical safety assessment.
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