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Physical & Chemical properties

Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 October - 21 December 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: n/a
- Specific activity: n/a
- Locations of the label: n/a
- Expiration date of radiochemical substance: n/a

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ca. 4 ºC in the dark and under nitrogen.
- Stability under test conditions: Assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: n/a
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: n/a

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: n/a
- Preliminary purification step (if any): n/a
- Final dilution of a dissolved solid, stock liquid or gel: n/a
- Final preparation of a solid: n/a

FORM AS APPLIED IN THE TEST (if different from that of starting material): n/a

OTHER SPECIFICS: n/a
Key result
Boiling pt.:
>= 204.9 - <= 205.9 °C
Atm. press.:
100.2 kPa
Decomposition:
no

Table 1       Thermographic data

Thermal Event

Interpretation

Temperature

Determination 1

Determination 2

ºC

K

ºC

K

Broad endotherm onset temperature

Boiling point onset

205.85

479.00

204.89

287.04

Conclusions:
The boiling point of the test item was 205.4 ± 0.5 ºC at 100.2 kPa.
Executive summary:

EU Method A.2 (2017) - The determination was carried out by differential scanning calorimetry, which was calibrated prior to use. Aliquots of test item (0.0050 - 0.0074 g) were placed in pre-pierced and were subjected to a thermal program from ambient to 450 °C at 20 °C/min, determinations 1 and 2 were under an air atmosphere and determinations 3 and 4 were under a nitrogen atmosphere. The appearance of the samples was observed before and after (residue) thermal analysis and their weight change were recorded after the test.

The thermographic data was used to determine the boiling point of the the test item as 205.4 ± 0.5 ºC at 100.2 kPa.

Description of key information

Boiling Point = 205.4 ± 0.5 ºC at 100.2 kPa; EU Method A.2, Anon. (2017)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
205.4 °C

Additional information

In a study conducted in accordance with EU Method A.2, the determination was carried out by differential scanning calorimetry, which was calibrated prior to use. Aliquots of test item (0.0050 - 0.0074 g) were placed in pre-pierced and were subjected to a thermal program from ambient to 450 °C at 20 °C/min, determinations 1 and 2 were under an air atmosphere and determinations 3 and 4 were under a nitrogen atmosphere. The appearance of the samples was observed before and after (residue) thermal analysis and their weight change were recorded after the test.

The thermographic data was used to determine the boiling point of the the test item as 205.4 ± 0.5 ºC at 100.2 kPa.