Registration Dossier
Registration Dossier
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EC number: 619-171-3 | CAS number: 95759-44-7
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-08-21 to 2006-08-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was performed as pretest for a OECD 305 bioconcentration study. The pre test was performed according to GLP and the methods applied are fully compliant with OECD TG 203.
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Principles of method if other than guideline:
- Solubilizer used to achieve exposure
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4'-ethyl-3-fluoro-4-(4-propylphenyl)-1,1'-biphenyl
- EC Number:
- 619-171-3
- Cas Number:
- 95759-44-7
- Molecular formula:
- C₂₃H₂₃F
- IUPAC Name:
- 4'-ethyl-3-fluoro-4-(4-propylphenyl)-1,1'-biphenyl
- Test material form:
- solid: bulk
Constituent 1
- Specific details on test material used for the study:
- Purity: > 99 %
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- HCO-40: 12 g/L
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- Species: Oryzias latipes
Charge: 080781
Weight: 0.3 g
Length: 3.1 (2.9 - 3.4) cm
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- According to guideline
- Test temperature:
- 25 °C
- pH:
- According to guideline
- Dissolved oxygen:
- According to guideline
- Salinity:
- According to guideline
- Nominal and measured concentrations:
- 100 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: solubiliser was used to achieve max exposure
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Solubiliser was used to achieve max concentration
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Study Design
The acute toxicity of the test material was studied in a pretest for a bioaccumulation study (OECD TG 305) using solvents to increase exposure. The GLP test was performed according to the METI Guideline: Concentration Test on Chemical Substances in Fish.
To achive the exposure concentrations, solvent HCO-40 was used. All concentrations tested were at or above the solubility limit of the pure test substance. For the test Oryzias latipes was used. The assay was perfomred as limit test using a single nominal test material concentration of 100 mg/L.
Results
In this limit test all fish survived the experimental phase of 96 h. No clinical signs have been observed. The 96 hours NOEC exceeds 100 mg/L nominal test material concentration.
Conclusion
The NOEC of the test material with solubilizer exceeds nominal 100 mg/L. - Executive summary:
Study Design
The acute toxicity of the test material was studied in a pretest for a bioaccumulation study (OECD TG 305) using solvents to increase exposure. The GLP test was performed according to the METI Guideline: Concentration Test on Chemical Substances in Fish.
To achive the exposure concentrations, solvent HCO-40 was used. All concentrations tested were at or above the solubility limit of the pure test substance. For the test Oryzias latipes was used. The assay was perfomred as limit test using a single nominal test material concentration of 100 mg/L.
Results
In this limit test all fish survived the experimental phase of 96 h. No clinical signs have been observed. The 96 hours NOEC exceeds 100 mg/L nominal test material concentration.
Conclusion
The NOEC of the test material with solubilizer exceeds nominal 100 mg/L.
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