Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-08-21 to 2006-08-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study was performed as pretest for a OECD 305 bioconcentration study. The pre test was performed according to GLP and the methods applied are fully compliant with OECD TG 203.

Data source

Reference
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Principles of method if other than guideline:
Solubilizer used to achieve exposure
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Purity: > 99 %

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
yes
Details on test solutions:
HCO-40: 12 g/L

Test organisms

Test organisms (species):
Oryzias latipes
Details on test organisms:
Species: Oryzias latipes
Charge: 080781
Weight: 0.3 g
Length: 3.1 (2.9 - 3.4) cm

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h

Test conditions

Hardness:
According to guideline
Test temperature:
25 °C
pH:
According to guideline
Dissolved oxygen:
According to guideline
Salinity:
According to guideline
Nominal and measured concentrations:
100 mg/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: solubiliser was used to achieve max exposure
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Solubiliser was used to achieve max concentration

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The NOEC of the test material with solubilizer exceeds nominal 100 mg/L.
Executive summary:

The informtion for this endpoint study record was obtained from an experimental study. The OECD GLP criteria were met and the methods applied are fully compliant with OECD TG 203. The NOEC of the test material with solubilizer exceeds nominal 100 mg/L.