4''-Ethyl-2'-fluor-4-propyl-1,1':4',1''-terphenyl

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2007-07-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

Directive 92/69/EEC

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

< 0.004 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

pH:

>= 6.21 - <= 6.48

Approximately 0.25 g of test substance was weighed into an amber ampoule, 10 mL of redistilled water was added, the solution was sonicated for 15 min. in the ultrasonic bath, and the ampoule was subsequently welded tight. Sets of three ampoules each (triplicate determination) were affixed in the shaking water bath (Haake SWB 25) immediately and after 24 and 48 hours, and all sample sets were shaken at 30°C for a further 24 hours. The temperature was then reduced to 20°C and the ampoules were shaken for a further 24 hours to ensure a thorough mixture.

 

Preparation of the test solution and determination

At the end of the mixing time the ampoules were broken open and the aqueous solutions filtered over a filter unit (Schleicher and Schuell, type Spartan 30/0.20 μm RC). Subsequently the appearance of a samples was assessed and the pH measured. The concentration of the sample solutions was determined by HPLC.

 

	Sample 1	Sample 2	Sample 3
Equilibration time	72 h	72 h	72 h
weighed portion/volume	0.25 g/10 mL	0.25 g/10 mL	0.25 g/10 mL
Equlibration temperature	30.0 °C	30.0 °C	30.0 °C
Test temperature	20.0 °C	20.0 °C	20.0 °C
appearance of solution	clear	clear	clear
pH-Value	6.48	6.44	6.48
Determined assay	<0.004 mg/L	<0.004 mg/L	<0.004 mg/L
Results	Mean <0.004 mg/L
	Sample 1	Sample 2	Sample 3
Equilibration time	48 h	48 h	48 h
weighed portion/volume	0.25 g/10 mL	0.25 g/10 mL	0.25 g/10 mL
Equlibration temperature	30.0 °C	30.0 °C	30.0 °C
Test temperature	20.0 °C	20.0 °C	20.0 °C
appearance of solution	Clear	clear	clear
pH-Value	6.25	6.21	6.30
Determined assay	<0.004 mg/L	<0.004 mg/L	<0.004 mg/L
Results	Mean <0.004 mg/L
	Sample 1	Sample 2	Sample 3
Equilibration time	24 h	24 h	24 h
weighed portion/volume	0.25 g/10 mL	0.25 g/10 mL	0.25 g/10 mL
Equlibration temperature	30.0 °C	30.0 °C	30.0 °C
Test temperature	20.0 °C	20.0 °C	20.0 °C
appearance of solution	clear	clear	clear
pH-Value	6.42	6.41	6.26
Determined assay	<0.004 mg/L	<0.004 mg/L	<0.004 mg/L
Results	Mean <0.004 mg/L

 

 

Overall results

Mean (72 h, 48 h, 24 h)  <0.004 mg/L

 

 

The water solubility at 20 °C was <0.004 mg/L

 

The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The Flask method showed a solubility:cs = <0.004 mg/L.

Conclusions:

The water solubility at 20 °C was:< 0.004 mg/L

Executive summary:

The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The Flask method showed a solubility:cs = <0.004 mg/L.

Description of key information

The water solubility cs of the test item at a temperature of 20°C was determined according to the flask method. It was found to be: cs = <0.004 mg/L.

Additional information

The water solubility was determined according to OECD 105 using the flask method. The preliminary test showed that the water solubility of the test item is < 10 mg/L. The Flask method showed a solubility:cs = <0.004 mg/L.