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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Information from migrated NONS file, as per inquiry number 06-2120053135-66-0000, permission to refer granted by ECHA

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Maximisation test)
GLP compliance:
yes
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
Information from migrated NONS file

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
EC Number:
401-100-0
EC Name:
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate
Cas Number:
109037-78-7
Molecular formula:
not applicable
IUPAC Name:
dititanium(4+) triethanolate bis(propan-1-olate) dibutyl phosphate butyl phosphate

In vivo test system

Test animals

Species:
guinea pig

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
Concentration of test material and vehicle used at induction:
a) 0.5% v/v in acetone containing 5% w/v alembicol D
b) Undiluted
Concentration of test material and vehicle used for each challenge:
20% and 50% v/v in acetone
Challenge
Concentration / amount:
Concentration of test material and vehicle used at induction:
a) 0.5% v/v in acetone containing 5% w/v alembicol D
b) Undiluted
Concentration of test material and vehicle used for each challenge:
20% and 50% v/v in acetone
No. of animals per dose:
Number of animals in test group: 20
Number of animals in negative control group: 20

Results and discussion

Positive control results:
Evidence of sensitisation of each challenge concentration: Evidence of sensitisation was observed in 3 animals.

In vivo (non-LLNA)

Resultsopen allclose all
Key result
Reading:
other: Not available - summary provided by ECHA 2014
Group:
test chemical
Dose level:
20% and 50%
No. with + reactions:
3
Total no. in group:
20
Clinical observations:
Evidence of sensitization at each concentration.
Remarks on result:
no indication of skin sensitisation
Key result
Reading:
other: Not available - summary provided by ECHA 2014
Group:
negative control
Dose level:
20% and 50% v/v
Total no. in group:
20
Clinical observations:
Not available - summary provided by ECHA 2014
Remarks on result:
other: Not available - summary provided by ECHA 2014
Key result
Reading:
other: Not available - summary provided by ECHA 2014
Group:
positive control
Dose level:
Not available - summary provided by ECHA 2014
Clinical observations:
Not available - summary provided by ECHA 2014
Remarks on result:
other: Not available - summary provided by ECHA 2014

Any other information on results incl. tables

Evidence of sensitisation of each challenge concentration: Evidence of sensitisation was observed in 3 animals.

Applicant's summary and conclusion

Interpretation of results:
other: not classified