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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID DATASET of CAS 497–19–8
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID DATASET, EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of Sodium carbonate (497–19–8) was performed in mouse.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium carbonate
Cas Number:
497-19-8
Molecular formula:
CH2O32Na
IUPAC Name:
Disodium carbonate
Details on test material:
- Name of test material (IUPAC name): Carbonic acid disodium salt
- Common name: Sodium carbonate
- Molecular formula: CH2O3.2Na
- Molecular weight: 105.988 g/mol
- Smiles notation: C(=O)([O-])[O-].[Na+].[Na+]
- InChl: 1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):Sodium carbonate
- Molecular formula :CH2O3.2Na
- Molecular weight :105.988 g/mole
- Substance type:Organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2210 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 210 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% Mortality was observed in treated mouse at 2210 mg/kg bw
Mortality:
50% Mortality was observed in treated mouse at 2210 mg/kg bw
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be 2210 mg/kg bw,when mice were treated with Sodium carbonate (497–19–8) by dermal application.
Executive summary:

In acute dermal toxicity study,mice were treated with Sodium carbonate(497–19–8)in the concentration of 2210 mg/kg bw by dermal application.50% mortality was observed in treated mice at dose 2210 mg/kg bw.Therefore, LD50 value was considered to be 2210 mg/kg bw,when mice were treated with Sodium carbonate(497–19–8)  by dermal application.

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