Registration Dossier
Registration Dossier
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EC number: 445-890-5 | CAS number: 201290-01-9
Endpoint summary
Administrative data
Description of key information
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Selenastrum capricornutum) for a mixed pre-hydrolysed solution prepared from the registration substance. The relevant short-term values are:
Fish: 96 h LC50 > 250 (mg initial nominal concentration of parent/L); 96 h LC50 > 40 (mg dihydroxy hydrolysis product/L); 96 h LC50 > 54 (mg trimethylsilanol hydrolysis product/L) (note: hydrolysis product concentrations at the LC50 measured in the mixed pre-hydrolysed solution. The LC50 exceeds the concentration used in this limit test).
Daphnia: 48 h EC50 > 250 (mg initial nominal concentration of parent /L); 48 h EC50 > 87 (mg dihydroxy hydrolysis product /L); 48 h EC50 > 115 (mg trimethylsilanol hydrolysis product/L)
Algae: 72 h ErC50 = 125 (mg initial nominal concentration of parent/L); 72 h ErC50 = 41 (mg dihydroxy hydrolysis product (geo mean)/L); 72 h ErC50 = 58 mg trimethylsilanol hydrolysis product (geo mean)/L); 72 h ErC10 = 77 (mg initial nominal concentration of parent/L); 72 h ErC10 = 22 (mg dihydroxy hydrolysis product (geo mean)/L); 72 h ErC10 = 30 mg trimethylsilanol hydrolysis product (geo mean)/L). Note: NOECs from this study appear to be more representative of the area under the growth curve (AUC) effects examined in the study alongside growth rate.
An activated sludge respiration inhibition 3 hour EC50 value of >100 mg/l (nominal) were determined in a reliable study.
The very rapid hydrolysis of the registration substance means it is likely that the test organisms in each test were exposed primarily to the hydrolysis products, 3-(dihydroxymethylsilyl)propylamine, trimethylsilanol and ethanol.
Additional information
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