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Physical & Chemical properties

Water solubility

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Description of key information

Under the conditions of the study, the average measured water solubility of NOVEC 7700 is 0.407 μg/L (RSD = 28%).

Key value for chemical safety assessment

Additional information

The water solubility of NOVEC 7700 was determined according to the U.S. EPA guidance document OPPTS 830.7840 “Water Solubility: Column Elution Method; Shake Flask Method”. Triplicate samples were prepared by injecting 100 μl of NONEV 7700 into the test vials pre-filled with Milli-Q reagent water to zero-headspace. The vials were incubated at approximately 30°C with shaking at 100 rpm for total of nine time points: The initial 5 time points (3, 4, 5, 6 and 10 days), and additional second 4 time points (6, 8, 10 and 13 days). Time intervals for the second sample preparation were selected to overlap the previous time points. At the end of each time point, the vials were centrifuged at a setting of 1500 rpm for 60 minutes, then allowed to equilibrate for at least 24 hour. Triplicate aliquot of 5 mL of the aqueous solution were removed from the test vial and transferred to a separate vial containing 5 mL of MilliQ water, and analyzed using purge and trap gas chromatography/mass spectrometry. The overall average of water solubility was 0.407 μg/L (RSD = 28%). This is a guideline study conducted under GLP. Therefore, it is considered reliable without restriction (Klimisch 1) and a key study.


A previous experiment was performed on one sample of water saturated with NOVEC 7700. The sample was dissolved and diluted to 10 % (W/W) in stabilized THF spiked with 1 ppm (W/W) DCB as internal standard and analyzed using capillary gas chromatography with Electron Capture Detector (ECD). The concentration of NOVEC 7700 in water was less than the detection limit of 100 ppb. Therefore, the water solubility of NOVEC 7700 was reported as < 100 ppb under the condition of the study. This is a preliminary study with only one sample analyzed. The study was not conducted according to guideline or under GLP, it is considered insufficient for assessment (Klimisch 4) and a supporting study.