Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-915-4 | CAS number: 16883-16-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Eye Irritation of 532-32-1
- Author:
- IFA (GESTIS)
- Year:
- 2 017
- Bibliographic source:
- GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften), 2017
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate the ocular irritation potential of Sodium benzoate in humans
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium benzoate
- EC Number:
- 208-534-8
- EC Name:
- Sodium benzoate
- Cas Number:
- 532-32-1
- Molecular formula:
- C7H6O2.Na
- IUPAC Name:
- Sodium Benzoate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:Sodium benzoate
Molecular formula:C7H5O2Na
Molecular weight: 144.11 g/mol
Substance type: organic
Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:Sodium benzoate
Molecular formula:C7H5O2Na
Molecular weight: 144.11 g/mol
Substance type: organic
Physical state: Solid
Test animals / tissue source
- Species:
- other: humans
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- No data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: No data available
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation observed
- Other effects:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- Under the conditions of the study, sodium benzoate was not irritating to human eyes.
- Executive summary:
The ocular irritation potential of Sodium benzoate was evaluated in humans.
Sodium benzoate was instilled into human eyes and effects were observed (dose and duration not specified).
Under the conditions of the study, sodium benzoate was not irritating to human eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
