Registration Dossier
Registration Dossier
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EC number: 240-915-4 | CAS number: 16883-16-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from IUCLID Dataset.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset of CAS 760-67-8
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 19 – FEB - 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute dermal toxicity of 2-ethylhexanoyl chloride (760-67-8) in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexanoyl chloride
- EC Number:
- 212-081-1
- EC Name:
- 2-ethylhexanoyl chloride
- Cas Number:
- 760-67-8
- Molecular formula:
- C8H15ClO
- IUPAC Name:
- 2-ethylhexanoyl chloride
- Details on test material:
- - IUPAC Name: 2–ethylhexanoyl chloride
- Mol. formula: C8H15ClO
- Molecular Weight: 162.658 g/mole
- Smiles: C(=O)(Cl)[C@@H](CC)CCCC
- InChI: 1S/C8H15ClO/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: 2–ethylhexanoyl chloride
- Mol. formula: C8H15ClO
- Molecular Weight: 162.658 g/mole
- Smiles: C(=O)(Cl)[C@@H](CC)CCCC
- InChI: 1S/C8H15ClO/c1-3-5-6-7(4-2)8(9)10/h7H,3-6H2,1-2H3
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 2010 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 010 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 2010 mg/kg bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was considered to be > 2010 mg/kg bw, when rabbits were treated with 2-ethylhexanoyl chloride (760-67-8) by dermal application.
- Executive summary:
The acute dermal toxicity of 2-ethylhexanoyl chloride was tested in rabbits at the concentration of 2010 mg/kg bw. No mortality was observed at 2010 mg/kg bw. Therefore, LD50 was considered to be > 2010 mg/kg bw, when rabbits were treated with 2-ethylhexanoyl chloride (760-67-8) by dermal application.
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