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Description of key information

Key value for chemical safety assessment

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No data are available for the toxicokinetics of the test material in human and non-human species. Information on other primary alkylamines [C8 (1-octanamine), C10 (1-decanamine) and C12 (1-dodecanamine)- ] are useful to understand the expected toxicokinetic behavior of teh test material because they are of similar alkyl chain length and functionality.

 

The test material is expected to be well absorbed by all exposure routes. Following absorption, initial distribution parallels perfusion. Alkylamines are oxidatively deaminated by monoaminooxidases with concomitant formation of ammonia and the corresponding alkylamine aldehyde. Oxidative deamination decreases with increasing carbon chain length. Subsequently, the aldehydes are oxidised by aldehyde dehydrogenases to the corresponding carboxylic acids, which, in turn, are further metabolised by ß-oxidation. Carbon dioxide as a product from ß-oxidation is exhaled. Urinary excretion is a minor elimination pathway.