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Long-term toxicity to aquatic invertebrates

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Description of key information

No long-term toxicity to aquatic invertebrate studies were available for the test substance.

Key value for chemical safety assessment

Additional information

There are no data available and testing is not necessary for the following reasons:

1)      Long-term data endpoints for two trophic levels (algae and fish) are available, to which an assessment factor of 50 was applied to the lower of these two long-term endpoints (in this case, the algal NOEC).  According to the reported acute endpoints for fish and aquatic invertebrates, the fish is the more sensitive trophic level (LC50 = 1.4 mg/L for fish versus EC50 of 2.5 forD. magna).  The fish chronic test provides the long-term endpoint for the more sensitive trophic level. 

2)      The RCR (PEC/PNEC ratio) is several orders of magnitude below the level of concern of 1 (i.e., 1.13E-04).  Thus, it is extremely highly unlikely that aDaphnia magnalong-term result will be substantially lower (i.e., orders of magnitude) than the existing long-term endpoints to result in a RCR that would trigger concern (i.e., >10).  Based on this reasoning, there does not appear to be a need for an additional long-term endpoint to assess risk, regardless of the outcome of the bioaccumulation and persistence evaluations.