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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity of 3-Aminobenzenesulfonic acid in rats
Author:
J-CHECK
Year:
2010
Bibliographic source:
Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK - (2010)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity of 3-Aminobenzenesulfonic acid in rats
GLP compliance:
not specified
Test type:
other: Acute oral toxicity
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3-Aminobenzenesulfonic acid
- Molecular formula (if other than submission substance): C6H7NO3S
- Molecular weight (if other than submission substance): 173.20 g/mole
- Substance type: Organic
- Physical state: No data available
Purity 98.6%
- Impurities (identity and concentrations): 1.4 %
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3-Aminobenzenesulfonic acid
- Molecular formula (if other than submission substance): C6H7NO3S
- Molecular weight (if other than submission substance): 173.20 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
500, 1000, 2000 mg/kg
No. of animals per sex per dose:
Total: 30
500 mg/kg: 5 male, 5 female
1000 mg/kg: 5 male, 5 female
2000 mg/kg: 5 male, 5 female
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No effect on survival, clinical sign, body weight, gross pathology and histopathology
Mortality:
No mortality was observed in treated male and female rats.
Clinical signs:
When treated with 500 and 1000 mg/kg, diarrhea with soft feces on the administration day and the following day, and yellow-discolored urine on the administration day were observed in treated male and female rats.
Body weight:
No change in body weight of treated male and female rats.
Gross pathology:
No gross pathological changes were observed in treated male and female rats.
Other findings:
No histopathological changes were observed in treated male and female rats.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 2000 mg/kg bw when Crj:CD (SD) male and female rat were treated with 3-Aminobenzenesulfonic acid orally.
Executive summary:

In a acute oral toxicity study,Crj:CD (SD) male and female rats were treated with 3-Aminobenzenesulfonic acid in the concentration of 500, 1000, 2000 mg/kg orally. No effect on survival and body weight were observed in treated rats. Diarrhea with soft feces on the administration day and the following day, and yellow-discolored urine on the administration day were observed at 500 and 1000 mg/kg treated male and female rats. In addition, no gross pathological and histopathological changes were observed in treated male and female rats. Therefore,LD50 was considered to be> 2000 mg/kg bw whenCrj:CD (SD) male and female rat were treated with 3-Aminobenzenesulfonic acid orally.