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EC number: 244-435-6
CAS number: 21544-03-6
Rate of death:
The acute dermal LD50 of the test item in rats of both sexes observed
over a period of 14 days is greater than 4600 mg/kg.
5 male and 5 females per concentrations were treated at 3590 and 4640
mg/kg with the test item unchanged.
The test site was covered with an occlusive dressing during 24 hours and
wascleaned with lukewarm water and the reaction of the skin was
As no mortality occured during the test, animals were necropsied at the
end of 14 days observation period
Signs and symptoms
Within 24 hours after treatment the rats in all dosage groups showed
sedation, dyspnoea, curved position and ruffled fur. No local skin
irritation was seen.
The animals recovered from systemic symptoms within 8 to 14 days. They
were submitted at random to a necropsy at the end of the observation
Killed animals: No substance related gross organ changes were seen.
The test material has therefore practically no acute toxicity to the rat
by this route of administration.
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